منابع مشابه
PAK1 Protein Expression in the Auditory Cortex of Schizophrenia Subjects
Deficits in auditory processing are among the best documented endophenotypes in schizophrenia, possibly due to loss of excitatory synaptic connections. Dendritic spines, the principal post-synaptic target of excitatory projections, are reduced in schizophrenia. p21-activated kinase 1 (PAK1) regulates both the actin cytoskeleton and dendritic spine density, and is a downstream effector of both k...
متن کاملLack of tonotopic organization of the auditory cortex in schizophrenia
Background: Disorganization of tonotopy in the auditory cortex has been described in schizophrenia. Subjects with schizophrenia show little to no spatial organization of responses to different tone frequencies in the auditory cortex. Previous studies have called into question the use of MEG and the M100 response to assess tonotopy. This study seeks to replicate prior results of tonotopic disorg...
متن کاملStereological Assessments of Neuronal Pathology in Auditory Cortex in Schizophrenia
It has long been known that auditory processing is disrupted in schizophrenia. More recently, postmortem studies have provided direct evidence that morphological alterations to neurons in auditory cortex are implicated in the pathophysiology of this illness, confirming previous predictions. Potential neural substrates for auditory impairment and gray matter loss in auditory cortex in schizophre...
متن کاملEffect of neuregulin-1 on the auditory cortex in adult C57BL/6J mice
Objective(s): We sought to explore whether neuregulin-1(NRG1) would have a protective effect on the auditory cortices of adult C57BL/6J mice.Materials and Methods: We used RTPCR and Western blot (WB) to detect the expression of NRG1 and ERBB4 (the receptor of NRG1) in the auditory cortices of C57BL/6J mice of different ages (6–8 weeks an...
متن کاملThe distributed auditory cortex.
A synthesis of cat auditory cortex (AC) organization is presented in which the extrinsic and intrinsic connections interact to derive a unified profile of the auditory stream and use it to direct and modify cortical and subcortical information flow. Thus, the thalamocortical input provides essential sensory information about peripheral stimulus events, which AC redirects locally for feature ext...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 2007
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2007.02.007